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- Title
Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora.
- Authors
Carrillo-Ocampo, Danae; Bazaldúa-Gómez, Sugeyla; Bonilla-Barbosa, Jaime R.; Aburto-Amar, Rola; Rodríguez-López, Verónica
- Abstract
Castilleja tenuiflora (Orobanchaceae) has been used in Mexican traditional medicine as a treatment for cough, dysentery, anxiety, nausea and vomiting as well as hepatic and gastrointestinal diseases. The ethanolic extract of the aerial parts of Castilleja tenuiflora was separated by silica gel column chromatography. The fractions were evaluated using the induced edema acetate 12-O-tetradecanoylphorbol (TPA) anti-inflammatory activity model. The most active fraction was subjected to medium-pressure liquid chromatography (MPLC) with UV detection at 206 and 240 nm. The following iridoids were isolated: geniposidic acid, aucubin, bartioside, 8-epi-loganin, mussaenoside, and the phenylpropanoid verbascoside. The most active iridoid was geniposidic acid, which was more active than the control (indomethacin), and the least active iridoid was mussaenoside. 8-epi-Loganin, and mussaenoside have not been previously reported to be anti-inflammatory compounds. The results of these investigations confirm the potential of Mexican plants for the production of bioactive compounds and validate the ethnomedical use of Castilleja tenuiflora-like anti-inflammatory plants.
- Subjects
MEXICO; ANTI-inflammatory agents; IRIDOIDS; VERBASCOSIDE; OROBANCHACEAE; GASTROINTESTINAL disease treatment; TRADITIONAL medicine
- Publication
Molecules, 2013, Vol 18, Issue 10, p12109
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules181012109