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- Title
New Bioactive Alkyl Sulfates from Mediterranean Tunicates.
- Authors
Imperatore, Concetta; Aiello, Anna; D'Aniello, Filomena; Luciano, Paolo; Vitalone, Rocco; Meli, Rosaria; Mattace Raso, Giuseppina; Menna, Marialuisa
- Abstract
Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1-5) including three new molecules 1-3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1-3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.
- Subjects
BIOACTIVE compounds; ALKYL group; TUNICATA; CIONA; METABOLITES; SPECTRUM analysis; MACROPHAGES
- Publication
Molecules, 2012, Vol 17, Issue 11, p12642
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules171112642