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- Title
Using gene-targeted mice to investigate the pathophysiology of myocardial reperfusion injury.
- Authors
Jones, Steven P.; Lefer, David J.
- Abstract
The article investigates the pathophysiology of myocardial reperfusion injury using gene-targeted mice. Also, it discusses insights about hypercholesterolemia and vascular homeostasis gained from these gene-targeted mice. A well known risk factor for the development of coronary artery disease is elevated plasma lipid levels. Prospective studies have established that the risk of cardiac morbidity and mortality is directly related to the concentration of plasma cholesterol. Endothelial-derived nitric oxide is vital to maintain normal vascular function. Deficiency of endothelial Nitric oxide synthase places the microvasculature at exceptional risk for the development of vascular dysfunction and ultimately tissue injury.
- Subjects
MYOCARDIAL reperfusion; REPERFUSION injury; MICE; NITRIC oxide; PATHOLOGICAL physiology; ISCHEMIA; HYPERCHOLESTEREMIA; BLOOD lipids
- Publication
Basic Research in Cardiology, 2000, Vol 95, Issue 6, p499
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s003950070027