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- Title
Predictive and Prognostic Value of Early Disease Progression by PET Evaluation in Advanced Non-Small Cell Lung Cancer.
- Authors
Banna, Giuseppe Luigi; anile, Giuseppe; Russo, Giorgio; Vigneri, Paolo; Castaing, Marine; Nicolosi, Maurizio; Strano, Salvatore; Gieri, Stefania; Spina, Rosaria; Patanè, Domenico; Calcara, Giacomo; Fraggetta, Filippo; Marletta, Francesco; Stefano, alessandro; Ippolito, Massimo
- Abstract
Objective: To assess the predictive and prognostic value of progressive metabolic disease (PMD) by the use of early 18Fluorodeoxyglucose positron emission tomography (18FDG-PET) in patients with clinical stage IV non-small cell lung cancer (NSCLC) treated with first-line chemotherapy. Methods: An 18FDG-PET performed following the first cycle of chemotherapy (PET-1) was compared with a pretreatment 18FDG-PET (PET-0) and a computed tomography (CT) scan after the third cycle (CT-3). The primary endpoint was the positive predictive value (PPV) of PMD. Secondary endpoints included the prognostic value of PMD. Results: Eleven of 38 patients (29%) had a PMD by PET-1, and 15 (39%), including all patients with a PMD, experienced a progressive disease by CT-3. The PPV of PMD was 100% according to both the European Organization for Research and Treatment of Cancer (EORTC) criteria and the PET Response Criteria In Solid Tumors (PERCIST) (p value for both, <0.0001). Patients with a PMD by PET-1 had a median overall survival of 7.0 months versus 14.0 months for those without a PMD (p = 0.04, according to the EORTC criteria). Conclusions: Early 18FDG-PET assessment deserves further investigation for the identification of NSCLC patients who do not benefit from first-line chemotherapy.
- Subjects
METABOLIC disorders; COMPUTED tomography; DEOXY sugars; LUNG cancer; PROBABILITY theory; RADIOPHARMACEUTICALS; POSITRON emission tomography; TREATMENT effectiveness; PRE-tests &; post-tests; DISEASE progression; DESCRIPTIVE statistics; PROGNOSIS
- Publication
Oncology, 2017, Vol 92, Issue 1, p39
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000448005