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- Title
Possible α-Adrenoceptor Blocking Activity of Arotinolol (S-596), a New β-Adrenoceptor Blocking Agent in Isolated Dog Coronary Artery.
- Authors
Sakanashi, Matao; Miyamoto, Yoshimasa; Ito, Hirosumi; Takeo, Satoshi; Noguchi, Katsuhiko; Higa, Tomoyo
- Abstract
Effects of arotinolol on dog coronary arteries were investigated in vitro. In distal portions of left circumflex coronary arteries contracted with 3 × 10-2M KCl, norephinephrine relaxed the strips in a concentration-dependent fashion. Propranolol (10-6M) converted the norepinephrine-induced relaxations to contractions, and arotinolol (10-6-10-5M) inhibited the relaxations induced by norepinephrine in a concentration-dependent manner. In proximal portions of the strips after potassium-contracture, norephinephrine produced concentration-dependent contractions which were augmented by propranolol (10-6M) and inhibited by arotinolol (10-6-10-5M). These results suggest that arotinolol has an α-adrenoceptor blocking activity in addition to a β-adrenoceptor blocking action in dog coronary arteries. Copyright © 1984 S. Karger AG, Basel
- Publication
Pharmacology, 1984, Vol 29, Issue 4, p204
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000138014