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- Title
Increased Cyclin D1 in Human Pancreatic Cancer Is Associated with Decreased Postoperative Survival.
- Authors
Kornmann, Marko; Ishiwata, Toshiyuki; Itakura, Jun; Tangvoranuntakul, Pam; Beger, Hans G.; Korc, Murray
- Abstract
Cyclin D1 belongs to a family of protein kinases that have been implicated in cell cycle regulation. In the present study we characterized cyclin D1 expression in 6 cultured human pancreatic cancer cell lines and in normal and cancerous human pancreatic tissues. A 4.4-kb cyclin D1 mRNA transcript was present in all cell lines and in all pancreatic tissues. Cyclin D1 mRNA levels were 2.1-fold higher in the pancreatic cancers than in normal pancreatic tissues (p < 0.0002). Cancer patients with lower cyclin D1 levels (n = 16) had a median survival of 15.5 months whereas patients with higher levels (n = 16) had a median survival of 6.5 months (p < 0.007). These data indicate that cyclin D1 expression may serve as a predictor of postoperative survival in pancreatic cancer patients, and raise the possibility that treatment modalities blocking cyclin D1 activity may have a future role in the therapy of these patients.
- Subjects
CYCLINS; GROWTH factors; PANCREATIC cancer; ONCOLOGIC surgery; SURGERY
- Publication
Oncology, 1998, Vol 55, Issue 4, p363
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000011879