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- Title
Inhibitory Effect of Alkane-6,8-Diols, the Components of Safflower, on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin.
- Authors
Yasukawa, Ken; Akihisa, Toshihiro; Kasahara, Yoshimasa; Kaminaga, Tomohiro; Kanno, Hiroshi; Kumaki, Kunio; Tamura, Toshitake; Takido, Michio
- Abstract
Erythro-alkane-6,8-diols were isolated from the flowers of Carthamus tinctorius. 12-0-Tetradecanoylphorbol-13-acetate (TPA, 1 ug/ear), a tumor-promoting agent, was applied to the ears of mice to induce inflammation. Of 8 alkane-6,8-diols assayed, the C27, C31, C32, C33 and C35 alkane diols inhibited the inflammation. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.5-0.7 mg/ear. However, C21, C23 and C25 alkane-6,8-diols were found to have no effect. Furthermore, the mixture of erythro-alkane-6,8-diols from the flowers of C. tinctorius markedly suppressed the promoting effect of TPA on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene. Copyright © 1996 S. Karger AG, Basel
- Publication
Oncology, 1996, Vol 53, Issue 2, p133
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000227549