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- Title
Acetylator phenotype in patients with p-phenylenediamine allergy.
- Authors
Kawakubo, Y.; Nakamori, M.; Schöpf, E.; Ohkido, M.; Schöpf, E
- Abstract
<bold>Objective: </bold>p-Phenylenediamine (PPD) has been widely distributed as hair dye ingredient and may be responsible for contact dermatitis. Since not all the subjects exposed to PPD react to the substance, we tested a possible predisposing factor of cutaneous drug metabolism.<bold>Methods: </bold>Eighty-five patients were selected on the basis of their patch test result for PPD. The acetylator status of patients was estimated using HPLC analysis of urinary caffeine metabolites.<bold>Results: </bold>Among patients with a negative result for PPD, there were three groups, i.e. fast, intermediate and slow acetylators, just as in the healthy population. However, we could not find any rapid acetylator in the PPD-sensitive patient group, and slow acetylators were more often encountered in this group (p < 0.05).<bold>Conclusion: </bold>The acetylator phenotype might be a good marker for the cutaneous sensitivity to PPD.
- Subjects
AMINES; CAFFEINE; COMPARATIVE studies; CONTACT dermatitis; DYES &; dyeing; HAIR care products; HETEROCYCLIC compounds; HIGH performance liquid chromatography; RESEARCH methodology; MEDICAL cooperation; METABOLISM; RESEARCH; SKIN; SKIN tests; XANTHINE; PHENOTYPES; ENVIRONMENTAL exposure; EVALUATION research
- Publication
Dermatology (10188665), 1997, Vol 195, Issue 1, p43
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000245683