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- Title
Assessment of the Velopharyngeal Mechanism at Rest and During Speech in Children With 22q11.2DS: A Cross-Sectional Study.
- Authors
Kollara, Lakshmi; Perry, Jamie L.; Kirschner, Richard E.; Fang, Xiangming; Baylis, Adriane L.
- Abstract
Objective: Velopharyngeal dysfunction (VPD) associated with 22q11.2 deletion syndrome (22q11.2DS) has a complex etiology. This study had 3 aims: (1) assess differences in velopharyngeal and levator muscle configuration during rest versus sustained speech production (2) compare differences in velopharyngeal changes between children with and without 22q11.2DS (3) examine the relationship between adenoid thickness, pharyngeal depth, and velopharyngeal changes. Design: Cross-sectional. Methods: A total of 22 participants, 11 with 22q11.2DS and 11 controls with normal speech and velopharyngeal anatomy (ages 4-12 years), underwent nonsedated MRI at rest and during sustained /i/. Differences in velar and levator muscle contraction across the 2 different conditions were analyzed, using matched paired t -tests. Mean differences across participant groups were examined. Correlation analyses were also conducted. Results: When comparing differences between rest and sustained phoneme production (aim 1), significant (P <.05) differences were noted for all velar and levator muscle variables. For differences in velopharyngeal changes between children with and without 22q11.2DS (aim 2), VP ratio and effective VP ratio were noted to be significantly different. Pharyngeal depth and adenoid thickness were correlated with velar and levator muscle change measures and ratios (aim 3). Conclusion: Results from this study provide quantitative in vivo measurements of the contracted levator muscle and velum in young children with 22q11.2DS. Results demonstrated that VP ratio and EVP ratio are significantly different between children with and without 22q11.2DS and that pharyngeal depth is a strong clinical determinant of VPD in children with 22q11.2DS.
- Subjects
PHARYNX; DIGEORGE syndrome; RESEARCH; 22Q11 deletion syndrome; PHARYNGEAL muscles; IN vivo studies; CROSS-sectional method; VELOPHARYNGEAL insufficiency; MAGNETIC resonance imaging; QUANTITATIVE research; T-test (Statistics); ADENOIDS; DESCRIPTIVE statistics; RESEARCH funding; STATISTICAL correlation; DATA analysis software; SPEECH; CHILDREN
- Publication
Cleft Palate Craniofacial Journal, 2023, Vol 60, Issue 10, p1250
- ISSN
1055-6656
- Publication type
Article
- DOI
10.1177/10556656221100674