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- Title
Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery.
- Authors
Tak Kyu Oh; Kwanmien Kim; Sanghoon Jheon; Hei-jin Lee; Sang-Hwan Do
- Abstract
Background: Cholesterol plays an important role in the action of opioid analgesics, but its association with postoperative pain has not been clarified. Our study examined the association of pre- and postoperative total serum cholesterol (TSC), and change between the pre- and postoperative TSC levels with postoperative pain outcomes in patients with non-small cell lung cancer (NSCLC) who underwent video-assisted thoracoscopic surgery (VATS) lobectomy. Methods: We retrospectively reviewed medical records of patients with NSCLC who underwent VATS lobectomy at the Seoul National University Bundang Hospital in South Korea. We sought to determine the association between preoperative TSC, TSC on postoperative day (POD) 0-1, and pre- and postoperative changes in TSC by comparing numeric rating scale (NRS) scores on POD 0, 1, and 2 and total morphine equivalent consumption on POD 0-2. Multivariate linear regression analyses were used, and P < 0.05 was considered statistically significant. Results: A total of 1,720 patients with NSCLC who underwent VATS lobectomy were included in the analysis. The change in TSC, preoperative TSC, and postoperative TSC showed no associations with morphine equivalent consumption on POD 0-2 (P > 0.05). In addition, the changes in TSC, preoperative TSC, and postoperative TSC were not associated with postoperative NRS pain score on POD 0, 1, and 2 (P > 0.05). Conclusions: Our results indicated that no significant association was observed between pre- and postoperative TSC level and postoperative pain outcome after VATS lobectomy of the lung.
- Subjects
SOUTH Korea; CHEST endoscopic surgery; LOBECTOMY (Lung surgery); VIDEO-assisted thoracic surgery; NON-small-cell lung carcinoma; POSTOPERATIVE pain; BLOOD cholesterol; CHOLESTEROL
- Publication
Korean Journal of Anesthesiology, 2019, Vol 72, Issue 2, p135
- ISSN
2005-6419
- Publication type
Article
- DOI
10.4097/kja.d.18.00122