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- Title
Gene therapy: can neural stem cells deliver?
- Authors
Müller, Franz-Josef; Snyder, Evan Y.; Loring, Jeanne F.
- Abstract
Neural stem cells are a self-renewing population that generates the neurons and glia of the developing brain. They can be isolated, proliferated, genetically manipulated and differentiated in vitro and reintroduced into a developing, adult or pathologically altered CNS. Neural stem cells have been considered for use in cell replacement therapies in various neurodegenerative diseases, and an unexpected and potentially valuable characteristic of these cells has recently been revealed — they are highly migratory and seem to be attracted to areas of brain pathology such as ischaemic and neoplastic lesions. Here, we speculate on the ways in which neural stem cells might be exploited as delivery vehicles for gene therapy in the CNS.
- Subjects
NEURAL stem cells; NEURODEGENERATION; ISCHEMIA; GENE therapy; CELLS
- Publication
Nature Reviews Neuroscience, 2006, Vol 7, Issue 1, p75
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn1829