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- Title
An integrated approach to classifying neuronal phenotypes.
- Authors
Migliore, Michele; Shepherd, Gordon M.
- Abstract
Characterizing the functional phenotypes of neurons is essential for understanding how genotypes can be related to the neural basis of behaviour. Traditional classifications of neurons by single features (such as morphology or firing behaviour) are increasingly inadequate for reflecting functional phenotypes, as they do not integrate functions across different neuronal types. Here, we describe a set of rules for identifying and predicting functional phenotypes that combine morphology, intrinsic ion channel species and their distributions in dendrites, and functional properties. This more comprehensive neuronal classification should be an improvement on traditional classifications for relating genotype to functional phenotype.
- Subjects
PHENOTYPES; NEURONS; NERVOUS system; GENETICS; NEUROLOGY
- Publication
Nature Reviews Neuroscience, 2005, Vol 6, Issue 10, p810
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn1769