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- Title
Chemoprevention of breast cancer with selective oestrogen-receptor modulators.
- Authors
Jordan, V. Craig
- Abstract
Twenty years ago, a new therapeutic dimension was conceived that not only had the potential to treat and prevent osteoporosis, but to prevent breast and endometrial cancer at the same time. As osteoporosis was known to be caused by oestrogen withdrawal after menopause, whereas breast and endometrial cancer are caused by unopposed oestrogen action, the new tissue-selective oestrogens and anti-oestrogens, or selective oestrogen-receptor modulators (SERMs), had to recruit new networks to activate or suppress target tissues selectively. New medicines now promise to provide chemoprevention strategies for women at risk for the development of many diseases.
- Subjects
CANCER chemoprevention; BREAST cancer; SELECTIVE estrogen receptor modulators; OSTEOPOROSIS; ESTROGEN; MENOPAUSE; BREAST tumor prevention; PROTEIN metabolism; ENDOMETRIAL tumors; ANTINEOPLASTIC agents; BIOLOGICAL models; CHEMOPREVENTION; COMPARATIVE studies; MATHEMATICAL models; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TAMOXIFEN; THEORY; EVALUATION research; PHARMACODYNAMICS; PREVENTION
- Publication
Nature Reviews Cancer, 2007, Vol 7, Issue 1, p46
- ISSN
1474-175X
- Publication type
research
- DOI
10.1038/nrc2048