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- Title
Copy number variations in DCC/18q and ERBB2/17q are associated with disease-free survival in microsatellite stable colon cancer.
- Authors
Sefrioui, David; Vermeulin, Thomas; Blanchard, France; Chapusot, Caroline; Beaussire, Ludivine; Armengol‐Debeir, Laura; Sesboué, Richard; Gangloff, Alice; Hebbar, Mohamed; Copin, Marie‐Christine; Houivet, Estelle; Schwarz, Lilian; Clatot, Florian; Tuech, Jean‐Jacques; Bénichou, Jacques; Martin, Laurent; Bouvier, Anne‐Marie; Sabourin, Jean‐Christophe; Sarafan‐Vasseur, Nasrin; Frébourg, Thierry
- Abstract
We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ERBB2/17q and STK6/20q, were detected using a quantitative multiplex polymerase chain reaction of short fluorescent fragment (QMPSF) method. The primary end-point was the impact of the CNVs on the 4-year disease-free survival (DFS). The recurrence rate at 4 years was 20.9%, corresponding to 14% Stage II patients versus 31% Stage III patients ( p < 0.0001). The 4-year DFS was significantly decreased in patients with a loss at DCC/18q ( p = 0.012) and a gain at ERBB2/17q ( p = 0.041). The multivariate analysis demonstrated that Stage III, a loss at DCC/18q and a gain at ERBB2/17q were independent factors associated with DFS. A combination of DCC/18q and ERBB2/17q was also associated with relapse, with the hazard ratio increasing from 1 to 2.4 (95% confidence interval (CI), 1.5-4.1) and 3.1 (95% CI, 1.2-8.4) in the presence of 0, 1 or 2 alterations, respectively ( p = 0.0013). CNVs in DCC/18q and ERBB2/17q are significantly associated with DFS in Stage II-III MSS colon cancer.
- Publication
International Journal of Cancer, 2017, Vol 140, Issue 7, p1653
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.30584