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- Title
Biodegradable and Biocompatible P<sub>DL</sub>LA-PEG<sub>1k</sub>-P<sub>DL</sub>LA Diacrylate Macromers: Synthesis, Characterisation and Preparation of Soluble Hyperbranched Polymers and Crosslinked Hydrogels.
- Authors
Hughes, Alan; Hongyun Tai; Tochwin, Anna; Wenxin Wang
- Abstract
A series of PDLLA-PEG1k-PDLLA tri-block co-polymers with various compositions, i.e., containing 2-10 lactoyl units, were prepared via ring opening polymerisation of D,L-lactide in the presence of poly (ethylene glycol) (PEG) (Mn = 1000 g•mol-1 as the initiator and stannous 2-ethylhexanoate as the catalyst at different feed ratios. PDLLA-PEG1k-PDLLA co-polymers were then functionalised with acrylate groups using acryloyl chloride under various reaction conditions. The diacrylated PPDLLA-PEG1k-PDLLA (diacryl-PDLLA-PEG1k-PDLLA) were further polymerised to synthesize soluble hyperbranched polymers by either homo-polymerisation or co-polymerisation with poly(ethylene glycol) methyl ether methylacrylate (PEGMEMA) via free radical polymerisation. The polymer samples obtained were characterised by ¹H NMR (proton Nuclear Magnetic Resonance), FTIR (Fourier Transform Infra-red spectroscopy), and GPC (Gel Permeation Chromatography). Moreover, the diacryl-PDLLA-PEG1k-PDLLA macromers were used for the preparation of biodegradable crosslinked hydrogels through the Michael addition reaction and radical photo-polymerisation with or without poly(ethylene glycol) methyl ether methylacrylate (PEGMEMA, Mn = 475 g•mol-1) as the co-monomer. It was found that fine tuning of the diacryl-PDLLA-PEG1k-PDLLA constituents and its combination with co-monomers resulted in hydrogels with tailored swelling properties. It is envisioned that soluble hyperbranched polymers and crosslinked hydrogels prepared from diacryl-PDLLA-PEG1k-PDLLA macromers can have promising applications in the fields of nano-medicines and regenerative medicines.
- Subjects
COPOLYMERS; ACRYLATES; HYDROGELS; COLLOIDAL gels; REGENERATIVE medicine
- Publication
Processes, 2017, Vol 5, Issue 2, p18
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr5020018