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- Title
Structural Analysis of Bacillus subtilis Sigma Factors.
- Authors
Collins, Katherine M.; Evans, Nicola J.; Torpey, James H.; Harris, Jonathon M.; Haynes, Bethany A.; Camp, Amy H.; Isaacson, Rivka L.
- Abstract
Bacteria use an array of sigma factors to regulate gene expression during different stages of their life cycles. Full-length, atomic-level structures of sigma factors have been challenging to obtain experimentally as a result of their many regions of intrinsic disorder. AlphaFold has now supplied plausible full-length models for most sigma factors. Here we discuss the current understanding of the structures and functions of sigma factors in the model organism, Bacillus subtilis, and present an X-ray crystal structure of a region of B. subtilis SigE, a sigma factor that plays a critical role in the developmental process of spore formation.
- Subjects
BACILLUS subtilis; LIFE cycles (Biology); CRYSTAL structure; GENE expression; X-ray crystallography; FACTOR structure
- Publication
Microorganisms, 2023, Vol 11, Issue 4, p1077
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms11041077