We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Saffold cardiovirus and multiple sclerosis: no evidence for an association.
- Authors
Galama, Jochem M. D.; Zoll, Jan G.; Lanke, Kjerstin H.; Jong, Arjan S.; Melief, Jeroen; Huitinga, Inge; Verbeek, Marcel M.; Kuppeveld, Frank J. M.
- Abstract
Saffold cardiovirus, a newly discovered human cardiovirus, has close similarity with Theiler's murine encephalomyelitis virus ( TMEV) which can cause a chronic demyelinating encephalomyelitis in mice. In this study, we tested whether Saffold cardiovirus infection of the brain is associated with multiple sclerosis ( MS). Autopsy white matter samples from 19 MS and 9 normal brain donors were tested by polymerase chain reaction. All were negative. Paired cerebrospinal fluid and serum samples from 24 MS patients and 27 controls were tested for Saffold cardiovirus-specific oligoclonal bands, two patients and two controls reacted positive. We conclude that an association between Saffold cardiovirus and MS is highly improbable.
- Subjects
LABORATORY mice; THEILER'S murine encephalomyelitis virus; AUTOPSY; POLYMERASE chain reaction; IMMUNOLOGY; VIRUS diseases; MULTIPLE sclerosis diagnosis
- Publication
Annals of Clinical & Translational Neurology, 2014, Vol 1, Issue 8, p618
- ISSN
2328-9503
- Publication type
Article
- DOI
10.1002/acn3.82