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- Title
Rutin Aşılama Programına Dâhil Olan Çocuklarda Hepatit B Serolojisinin Retrospektif Olarak Değerlendirilmesi.
- Authors
KULA ATİK, Tuğba; GÜMÜŞ, Ersin; ÇETİN DURAN, Alev
- Abstract
Objective: The aim of the present study was to evaluate the seropositivity rate of anti-HBs antibodies in children who have been born since the implementation of the routine hepatitis B virus (HBV) vaccination program in Turkey. Material and Methods: The anti-HBs, HBsAg, anti-HBc immunoglobulin G and HBV-DNA results of the patients who applied to the pediatrics outpatient clinics of our hospital between January 2017 and December 2019 were retrospectively analyzed. Results: In our study, the anti-HBs value of 1,867 children were reached. The rate of innate immunity was found to be 0.2%, and the rate of chronic HBsAg carrier status was 0.3%. Following exclusion of patients who have been chronically infected or have recovered from the disease, it was determined that 69.4% of the 1,857 children were seropositive and 30.6% were seronegative for anti-HBs. A statistically significant difference was found between seropositive and seronegative groups in terms of gender, age, and serum anti-HBs level (p<0.001). There was a statistically significant difference between the age groups regarding anti-HBs level and anti-HBs seropositivity rate (p<0.001) both of which were higher in 0-5 years age group. Conclusion: Significant number of the children who have been born since the implementation of the routine HBV vaccination program with a high vaccination rate, had a decrease in anti-HBs levels over time, with the lowest levels being reached in adolescence. Despite the decrease in anti-HBs seropositivitiy rate, the number of patients who acquire natural immunity or have chronic infection was low. This can be interpreted as that vaccination protects against HBV infection in long-term, even if the anti-HBs titers decrease.
- Subjects
TURKEY; NATURAL immunity; HEPATITIS B virus; IMMUNOGLOBULIN G; HEPATITIS B vaccines; HEPATITIS B
- Publication
Turkiye Klinikleri Journal of Pediatrics / Türkiye Klinikleri Pediatri Dergisi, 2022, Vol 31, Issue 2, p93
- ISSN
1300-0381
- Publication type
Article
- DOI
10.5336/pediatr.2021-85990