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- Title
FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF GLICLAZIDE HYDROCHLORIDE.
- Authors
Shaikh, Siraj N.; Saad, Shaikh; Khan, G. J.; Pathan, Sharukh Y.
- Abstract
This article illustrates the Formulation and Characterization of Mucoadhesive microspheres of Gliclazide Hydrochloride. The mucoadhesive microspheres were prepared by the Emulsion Solvent Evaporation method by using Eudragit L 100 and Ethyl Cellulose 22 CPS polymers & PEG 4000 added as a pore forming agent. Formulated microspheres were evaluated for various parameters. The characteristics like shape and structure of prepared microspheres were determined by Optical microscopy and scanning electron microscopy respectively. The prepared microspheres exhibited prolonged drug release (12 hrs) the mean particle size increased as the concentration of Eudragit L 100 increased. Decrease in size of microspheres leads to decrease in mucoadhesion time, % drug loading and faster the drug release. The optimized formulation shows following cumulative release after 12 hrs i.e. 96.40%. The microspheres exhibited 80% mucoadhesion and showed good drug entrapment efficiency i.e. 80.13±0.91% as well as drug loading efficiency is 26.70±0.75%. It can be concluded that the present mucoadhesive microspheres can be an ideal system to deliver the Gliclazide Hydrochloride in the sustained release manner for management of Type II Diabetes Mellitus.
- Subjects
MICROSPHERES; GLICLAZIDE; CONTROLLED release drugs; TYPE 2 diabetes treatment; SCANNING electron microscopy
- Publication
Journal of Drug Delivery & Therapeutics, 2018, Vol 8, Issue 4, p117
- ISSN
2250-1177
- Publication type
Article
- DOI
10.22270/jddt.v8i4.1735