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- Title
The use of a specialised amino acid mixture for pressure ulcers: A placebo-controlled trial.
- Authors
Wong, A.; Chew, A.; Wang, C. M.; Ong, L.; Zhang, S. H.; Young, S.
- Abstract
Objective: To compare pressure ulcer healing rates in patients supplemented with a specialised amino acid mixture containing â-hydroxy â-methylbutyrate (HMB), arginine and glutamine, and standard oral nutritional supplements versus patients supplemented with oral nutritional supplements and a placebo mixture. Method: Twenty-three inpatients with stage II, III or IV pressure ulcers in an acute care hospital were randomised to receive (A) a HMB, arginine and glutamine mixture twice daily alongside oral nutritional supplements (n=11) or (B) standard nutritional care alongside oral nutritional supplements (n=12) for 2 weeks. Pressure ulcers were measured weekly for area, depth and Pressure Ulcer Scale for Healing (PUSH) scores. The proportion of viable tissue was determined based on area of wound tracing. Weekly laboratory tests were performed to measure C-reactive protein and pre-albumin levels. This trial is registered at http://ClinicalTrials.gov under NCT01090076. Results: There was no difference between anthropometrical measurements, biochemical parameters and nutritional intake pre- and post- study. Wound area did not decrease significantly in the short term for both groups. The proportion of viable tissues increased within 2 weeks on HMB, arginine and glutamine supplementation (p=0.02). PUSH scores showed significant improvement within 1 week of supplementation for the experimental group (p=0.013). Conclusion: The use of specialised amino acid does not appear to reduce wound size and PUSH scores but may improve tissue viability after 2 weeks. Further confirmation on a larger scale is required to determine the benefits of supplementing additional HMB, arginine and glutamine in patients with pressure ulcers.
- Subjects
SINGAPORE; AMINO acid analysis; BEDSORES treatment; ANALYSIS of variance; CONFIDENCE intervals; DIETARY supplements; FISHER exact test; HEALTH outcome assessment; RESEARCH funding; STATISTICS; T-test (Statistics); U-statistics; DATA analysis; RANDOMIZED controlled trials; TREATMENT effectiveness; REPEATED measures design; DATA analysis software; DESCRIPTIVE statistics
- Publication
Journal of Wound Care, 2014, Vol 23, Issue 5, p259
- ISSN
0969-0700
- Publication type
Article
- DOI
10.12968/jowc.2014.23.5.259