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- Title
Synthesis and Hemostatic Activity of Substituted Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates.
- Authors
Lipin, D. V.; Kozlov, D. A.; Shadrin, V. M.; Parkoma, K. Yu.; Starkov, A. V.; Shipilovskikh, D. A.; Pulina, N. A.; Shipilovskikh, S. A.
- Abstract
Ring opening in 2-[(2-oxofuran-3(2H)-yliden)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles under the action of various nitriles and t-BuOK was used to synthesize previously unknown substituted potassium 1-cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates. The structure of the obtained compounds was confirmed by 1H and 13C NMR spectroscopy and elemental analysis. The anticoagulant activity of the products was studied.
- Subjects
POTASSIUM; NUCLEAR magnetic resonance spectroscopy; ELEMENTAL analysis; NITRILES
- Publication
Russian Journal of Organic Chemistry, 2023, Vol 59, Issue 8, p1322
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428023080055