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- Title
Ring Opening of Substituted 3-[2-(4-Nitrobenzoyl)-hydrazinylidene]furan-2(3H)-ones with Primary Alcohols. Analgesic Activity and Acute Toxicity of the Products.
- Authors
Lipin, D. V.; Denisova, E. I.; Shipilovskikh, D. A.; Makhmudov, R. R.; Igidov, N. M.; Shipilovskikh, S. A.
- Abstract
Ring opening of 5-substituted 3-[2-(4-nitrobenzoyl)hydrazinylidene]furan-2(3H)-ones by the action of alcohols afforded the corresponding 4-substituted 2-[2-(4-nitrobenzoyl)hydrazinylidene]-4-oxobutanoates. The synthesized compounds were evaluated for analgesic activity and acute toxicity. They showed a pronounced analgesic effect in combination with low toxicity and can be regarded as almost nontoxic compounds.
- Subjects
ANALGESICS; ALCOHOL; CHEMICAL synthesis
- Publication
Russian Journal of Organic Chemistry, 2023, Vol 59, Issue 4, p631
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428023040103