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- Title
Architecture of the human mTORC2 core complex.
- Authors
Stuttfeld, Edward; Aylett, Christopher H. S.; Imseng, Stefan; Boehringer, Daniel; Scaiola, Alain; Sauer, Evelyn; Hall, Michael N.; Maier, Timm; Ban, Nenad
- Abstract
The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.
- Subjects
RAPAMYCIN; PROTEIN kinases; PROTEIN kinase structure; PROTEINS; REGULATION of cell metabolism; REGULATION of cell growth; BINDING sites; CELLULAR control mechanisms
- Publication
eLife, 2018, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.33101