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- Title
Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model.
- Authors
Ma, Xiaolei; Yang, Wende; Nie, Pan; Zhang, Zhenbin; Chen, Zehong; Wei, Hongbo
- Abstract
Background: This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury. Results: The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum. Conclusions: Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.
- Subjects
SCHWANN cells; NERVOUS system injuries; ANIMAL disease models; IMPOTENCE; SMOOTH muscle
- Publication
Basic & Clinical Andrology, 2023, Vol 33, Issue 1, p1
- ISSN
2051-4190
- Publication type
Article
- DOI
10.1186/s12610-023-00187-x