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- Title
Interleukin-8-producing primary cardiac undifferentiated sarcoma in a child with sustained fever.
- Authors
Yanagisawa, Ryu; Nakamura, Tomohiko; Ogiso, Yoshifumi; Hachiya, Akira; Fujihara, Ikuko; Morita, Daisuke; Sakashita, Kazuo; Kitamura, Masatomo; Matsui, Hikoro; Nishijima, Fumie; Hayashi, Hidetaka; Hidaka, Eiko; Sano, Kenji; Shiohara, Masaaki; Yasukochi, Satoshi
- Abstract
We report the case of a 12-year-old boy with primary undifferentiated sarcoma of the left atrium. He had sustained fever during the clinical course and multiple lung and brain metastases. Chemotherapy and irradiation were ineffective; he died 41 days after hospitalization. On retrospective analysis, interleukin-8 ( IL-8) was elevated; this was supported by immunohistochemistry and gene expression analysis of tumor samples. IL-8 continued to increase with tumor progression accompanied by elevated neutrophil count and C-reactive protein. IL-8 is involved in malignant tumor proliferation, migration, and angiogenesis and may have been related to the clinical condition and prognosis in the present case.
- Subjects
FEVER; HEART tumors; INTERLEUKINS; DISEASE complications
- Publication
Pediatrics International, 2015, Vol 57, Issue 4, p742
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1111/ped.12621