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- Title
Aptamer-PEG-modified Fe<sub>3</sub>O<sub>4</sub>@Mn as a novel T1- and T2- dual-model MRI contrast agent targeting hypoxia-induced cancer stem cells.
- Authors
Zhu, Haitao; Zhang, Lirong; Liu, Yanfang; Zhou, Yuepeng; Wang, Kang; Xie, Xiaodong; Song, Lian; Wang, Dongqing; Han, Chunlei; Chen, Qiuyun
- Abstract
Hypoxia-induced cancer stem cells have been known to be involved in tumour metastasis, resistance to chemo/radio therapy and tumour recurrence. Magnetic Resonance Imaging is a widely used imaging tool for cancers in clinics and research. To develop T1-positive and T2-negative dual mode MRI agents for more comprehensive and accurate diagnostic information under hypoxic conditions, a hypoxia-inducible factor-1α based aptamer and Mn(II)-modified nanoparticles D-Fe3O4@PMn were synthesized and characterized. In vitro and in vivo studies show that D-Fe3O4@PMn NPs are biocompatible and less cytotoxic and can produce significant contrast enhancement in T1- and T2-weighted MR imaging. Furthermore, the D-Fe3O4@PMn NPs enable targeted dual-contrast T1- and T2-weighted MR imaging of cancer cells expressing high levels of HIF-1α and cancer stem cell-related proteins under hypoxic condition. In conclusion, NPs with HIF-1α and Mn(II) are promising diagnostic agents for dual-mode T1 and T2 imaging by targeting cancer stem cells as they are non-toxic and biocompatible.
- Publication
Scientific Reports, 2016, p39245
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep39245