We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Three-dimensional ultrasound imaging and measurement of nasal bone length, prenasal thickness and frontomaxillary facial angle in normal second- and third-trimester fetuses.
- Authors
Vos, F. I.; De Jong-Pleij, E. A. P.; Ribbert, L. S. M.; Tromp, E.; Bilardo, C. M.
- Abstract
Objectives To assess the feasibility of nasal bone length (NBL), prenasal thickness (PT) and frontomaxillary facial (FMF) angle measurements performed on the same three-dimensional (3D) multiplanar-corrected profile view in healthy second- and third-trimester fetuses, to create reference ranges and to review published measurement techniques. Methods 3D volumes of 219 healthy second- and third-trimester fetuses were retrospectively analyzed. The quality of images and measurability of the markers were assessed with 5-point and 3-point scoring systems, respectively. Measurements of NBL (with care to exclude the frontal bone), PT and FMF were obtained in the exact mid-sagittal plane. Reference ranges were constructed based on measurements from images with high-quality (4 or 5 points) and high measurability (2 or 3 points) scores and compared with those in the most relevant published literature. Results A high-quality score was assigned to 111 images. Among these, a high measurability score was significantly more often achieved for NBL (98.2%) and PT (97.3%) than for the FMF angle (26.1%) ( P < 0.001). Both NBL (NBL = − 6.927 + (0.83 × GA) − (0.01 × GA 2)) and PT (PT = (0.212 × GA) − 0.873) (where GA = gestational age) showed growth with gestation, with less pronounced growth for NBL after 28 weeks. Our reference range for the NBL showed a systematically smaller length than those in other two-dimensional (2D) ultrasound-based publications. The FMF angle measurements that we obtained did not show a significant change with GA. Conclusions NBL and PT are easily measured using 3D ultrasound whereas FMF angle measurement is more challenging. When it is measured in the exact mid-sagittal plane and care is taken to exclude the frontal bone, measurements of the NBL are systematically smaller than those in previous 2D ultrasound-based publications. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
- Subjects
NASAL bone; GENETIC markers; GESTATIONAL age; ULTRASONIC imaging; SECOND trimester of pregnancy; THIRD trimester of pregnancy; FETUS
- Publication
Ultrasound in Obstetrics & Gynecology, 2012, Vol 39, Issue 6, p636
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.10058