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- Title
Anticancer activity of bovine α-lactalbumin treated with microbial transglutaminase.
- Authors
JEONG, JI-EUN; HONG, YOUN-HO
- Abstract
This study investigated the effects of bovine α-lactalbumin (α-La) treated with microbial transglutaminase on human cancer cells, cell cultures and growth rate assays. The anticancer activity for 10 mg/mL of bovine α-lactalbumin (α-La) was measured as ∼90% in a human colorectal cancer cell line HCT 116. For the human bone cancer cell line SJSA-1, α-La hydrolysis resulted in higher cytotoxicity compared to untreated tumour cells. The formation of polymers of α-La was suppressed by the addition of ethylenediaminetetraacetic acid, indicating that polymers of α-La are promoted by metal ions such as Ca2+. The effect of α-La on the morphology of SJSA-1 cells was manifested as morphological changes compatible with apoptosis. Bovine milk α-La with and without microbial transglutaminase is considered a valuable food ingredient and a nutraceutical for human health.
- Subjects
ANTINEOPLASTIC agents; LACTALBUMIN; CANCER cells; CELL lines; TRANSGLUTAMINASES
- Publication
International Journal of Dairy Technology, 2012, Vol 65, Issue 2, p212
- ISSN
1364-727X
- Publication type
Article
- DOI
10.1111/j.1471-0307.2012.00820.x