We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Beneficial effects of extended-release doxazosin and doxazosin standard on sexual health.
- Authors
Kaplan, Steven A.; de Rose, Aldo F.; Kirby, Roger S.; O'Leary, Michael P.; McVary, Kevin T.
- Abstract
The prevalence of benign prostatic hypertrophy (BPH) and erectile dysfunction (ED) both increase with age, and increasing evidence suggests a common cause rather than independent age-related changes. Arterial hypertension often accompanies these urological disorders, suggesting the possibility that increased α-adrenoceptor activity may be causal in all three conditions. As evidence for this model, α-adrenoceptor antagonists such as doxazosin produce therapeutically beneficial effects in lowering blood pressure, reducing prostate growth and BPH symptoms, and relieving ED. At postjunctional α1-receptors in the corpus cavernosa, noradrenaline causes vascular smooth muscle cell contraction, restricting blood flow, resulting in penile detumescence. Just as α-adrenoceptor antagonism results in systemic vasorelaxation to lower blood pressure, the same mechanism in the penis modulates the effects of noradrenaline to favour vasodilatation, resulting in improved erectile function. Increasing clinical evidence attests to the effectiveness of doxazosin in relieving ED, even in patients refractory to ED-specific treatment, as well as in reducing BPH symptoms and elevated blood pressure.
- Subjects
IMPOTENCE; URINARY organs; PROSTATE hypertrophy; BLOOD pressure; VASCULAR smooth muscle; HYPERTENSION
- Publication
BJU International, 2006, Vol 97, Issue 3, p559
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/j.1464-410X.2005.05959.x