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The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases.
Published in:
Frontiers in Pharmacology, 2021, v. 11, p. 1, doi. 10.3389/fphar.2021.656561
By:
- Correia, Susana S.;
- Iyengar, Rajesh R.;
- Germano, Peter;
- Tang, Kim;
- Bernier, Sylvie G.;
- Schwartzkopf, Chad D.;
- Tobin, Jenny;
- Lee, Thomas W.-H.;
- Liu, Guang;
- Jacobson, Sarah;
- Carvalho, Andrew;
- Rennie, Glen R.;
- Jung, Joon;
- Renhowe, Paul A.;
- Lonie, Elisabeth;
- Winrow, Christopher J.;
- Hadcock, John R.;
- Jones, Juli E.;
- Currie, Mark G.
Publication type:
Article
The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system.
Published in:
2021
By:
- Correia, Susana S.;
- Liu, Guang;
- Jacobson, Sarah;
- Bernier, Sylvie G.;
- Tobin, Jenny V.;
- Schwartzkopf, Chad D.;
- Atwater, Emily;
- Lonie, Elisabeth;
- Rivers, Sam;
- Carvalho, Andrew;
- Germano, Peter;
- Tang, Kim;
- Iyengar, Rajesh R.;
- Currie, Mark G.;
- Hadcock, John R.;
- Winrow, Christopher J.;
- Jones, Juli E.
Publication type:
journal article
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats.
Published in:
Pharmacology Research & Perspectives, 2020, v. 8, n. 2, p. 1, doi. 10.1002/prp2.579
By:
- Banijamali, Ali R.;
- Carvalho, Andrew E.;
- Wakefield, James D.;
- Germano, Peter;
- Barden, Timothy C.;
- Tobin, Jenny V.;
- Zimmer, Daniel P.;
- Masferrer, Jaime L.;
- Profy, Albert T.;
- Currie, Mark G.;
- Todd Milne, G.
Publication type:
Article
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.
Published in:
Nature Biotechnology, 2003, v. 21, n. 2, p. 150, doi. 10.1038/nbt781
By:
- Askenazi, Manor;
- Driggers, Edward M.;
- Holtzman, Douglas A.;
- Norman, Thea C.;
- Iverson, Sara;
- Zimmer, Daniel P.;
- Boers, Mary-Ellen;
- Blomquist, Paul R.;
- Martinez, Eduardo J.;
- Monreal, Alex W.;
- Feibelman, Toby P.;
- Mayorga, Maria E.;
- Maxon, Mary E.;
- Sykes, Kristie;
- Tobin, Jenny Vittum;
- Cordero, Etchell;
- Salama, Sofie R.;
- Trueheart, Joshua;
- Royer, John C.
Publication type:
Article
Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease.
Published in:
Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2020.00419
By:
- Zimmer, Daniel P.;
- Shea, Courtney M.;
- Tobin, Jenny V.;
- Tchernychev, Boris;
- Germano, Peter;
- Sykes, Kristie;
- Banijamali, Ali R.;
- Jacobson, Sarah;
- Bernier, Sylvie G.;
- Sarno, Renee;
- Carvalho, Andrew;
- Chien, Yueh-tyng;
- Graul, Regina;
- Buys, Emmanuel S.;
- Jones, Juli E.;
- Wakefield, James D.;
- Price, Gavrielle M.;
- Chickering, Jennifer G.;
- Milne, G. Todd;
- Currie, Mark G.
Publication type:
Article
Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo.
Published in:
PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0141330
By:
- Ranganath, Sheila;
- Bhandari, Ashok;
- Avitahl-Curtis, Nicole;
- McMahon, Jaimee;
- Wachtel, Derek;
- Zhang, Jenny;
- Leitheiser, Christopher;
- Bernier, Sylvie G.;
- Liu, Guang;
- Tran, Tran T.;
- Celino, Herodion;
- Tobin, Jenny;
- Jung, Joon;
- Zhao, Hong;
- Glen, Katie E.;
- Graul, Chris;
- Griffin, Aliesha;
- Schairer, Wayne C.;
- Higgins, Carolyn;
- Reza, Tammi L.
Publication type:
Article

Found: 6

The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases.

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system.

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats.

Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease.

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo.