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- Title
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF REPAGLINIDE.
- Authors
Patil, Hitesh A.; Tadvi, S. A.; Pawar, S. P.
- Abstract
The present study involves preparation and evaluation of floating tablet of Repaglinide prolongation of gastric resident time. The tablets were prepared by direct compression method using polymer HPMC (K 100M, HPMC E15) & Xanthun gum. The tablets were evaluated for Angle of repose, Bulk density, Tapped density, Carr's index Hausner ratio. The prepared tablets were characterized by size & Shape, Hardness, Thickness, Friability, Weight variation and drug content respectively. In-vitro drug release studies were performed by using an USP dissolution test apparatus-II (Basket type) at 37 + 0.5 °C and 50 rpm speed. To study the release behavior were performed on the optimized formulation. The prepared tablet exhibited prolonged drug release (12 hr.) and remained buoyant for > 12 hr. The optimized formulation F7 was kept for short term stability study. The conditions for stability study were 40°c and relative humidity of 75% from the study; it was observed that there is no significant change in stability and drug release rate.
- Subjects
DRUG dosage; HYPOGLYCEMIC agents; POLYMER analysis; ETHYLCELLULOSE; PECTINS
- Publication
Pharma Science Monitor, 2017, Vol 8, Issue 2, p285
- ISSN
0976-9242
- Publication type
Article