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- Title
Hemostatic efficacy of fibrin sealant patch (TachoSil®) in the loop electrosurgical excisional procedure: a prospective randomized controlled study.
- Authors
Jeong-Yeol Park; Junhwan Kim; Joo-Hyun Nam
- Abstract
Objective: To evaluate the hemostatic efficacy of the fibrin sealant patch (TachoSil®) after loop electrosurgical excision procedure (LEEP) and its influence on other complications and quality of life (QoL). Methods: This single-blind, prospective, randomized study involved patients undergoing LEEP with or without TachoSil (1:1) between August 2014 and August 2015 in Asan Medical Center, Korea. Primary outcome measures were bleeding duration and the frequency of additional treatment owing to vaginal bleeding within 2 weeks post-LEEP. Secondary outcome measures were vaginal bleeding volume using pictorial blood loss assessment chart (PBAC) score, the amount of vaginal discharge, the frequency of external genitalia, vaginal, and cervical infections within 2 weeks post-LEEP, and changes in QoL. Results: Of the 140 patients enrolled, 126 (90.0%) were successfully followed up and analyzed. The median vaginal bleeding duration and frequency of additional treatment owing to vaginal bleeding showed no significant difference in the TachoSil applied and non-applied groups (p=0.96 and p=0.61, respectively). Also, no significant difference was also observed in vaginal bleeding volume between two groups (p=0.64). In subgroup analysis for patients who underwent large-size LEEP (the longest dimension of ≥2 cm), significant improvement was observed at physical functioning in QoL at 23 (p=0.03) and 6 weeks (p=0.03) post-LEEP of the TachoSil applied group, compared to the non-applied group. Conclusion: TachoSil did not demonstrate significant hemostatic efficacy after LEEP. However, TachoSil improved patient recognition on physical function in patients who underwent large-size LEEP.
- Subjects
FIBRIN; UTERINE hemorrhage; SEALING compounds; PHYSICAL mobility; VAGINAL discharge; ELECTROSURGERY; CONIZATION
- Publication
Journal of Gynecologic Oncology, 2024, Vol 35, p36
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2024.35.S2.P31