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- Title
Impact of peritoneal vaginoplasty combined with radical hysterectomy on the quality of sexual life for patients with early-stage cervical cancer: trial protocol for a multi-center superiority randomized controlled trial.
- Authors
Shimin Yang; Yan Ding; Huaifang Li; Sufang Wu; Weiwei Feng; Yudong Wang; Xipeng Wang; Keqin Hua
- Abstract
Background: Radical hysterectomy (RH) is commonly used to treat early-stage cervical cancer in women of childbearing age and sexual dysfunction due to postoperative vaginal shortening is a major concern. The impact of intraoperative vaginoplasty on prognosis and quality of sexual life in patients with early-stage cervical cancer remains controversial and lacks high-level evidence. However, there are few reports on vaginoplasty after RH to lengthen vagina in patients. This prospective, multi-center, randomized controlled trial aims to explore the impact of peritoneal vaginoplasty with or without ovarian transposition after laparoscopic RH on sexual dysfunction in patients with early-stage cervical cancer. Methods: Eligible patients will be randomly assigned (1:1) to receive peritoneal vaginoplasty or not. The primary evaluation indicators are female sexual function index (FSFI) and male sexual satisfaction scale. The secondary evaluation indicators include EORTC QLQ-CX24, 2-year overall survival (OS), 5-year OS, 2-year progression-free survival (PFS), 5-year PFS and surgery-related complications. The trial will enroll 368 patients from 6 hospitals in China over a 3-year period and follow up for 5 years.
- Subjects
CHINA; VAGINOPLASTY; TRACHELECTOMY; CERVICAL cancer; QUALITY of life; HYSTERECTOMY; SEXUAL excitement; CHILDBEARING age
- Publication
Journal of Gynecologic Oncology, 2024, Vol 35, Issue 3, p1
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2024.35.e23