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- Title
Association of Tumor Necrosis Factor-α Inhibitors with Incident Dementia: Analysis Based on Population-Based Cohort Studies.
- Authors
Berger, Saskia; Moseholm, Kristine F.; Hegelund, Emilie R.; Tesch, Falko; Nguyen, Minh Chau S.; Mortensen, Laust H.; Jensen, Majken K.; Schmitt, Jochen; Mukamal, Kenneth J.
- Abstract
Background and Objective: Preliminary evidence suggests a possible preventive effect of tumor necrosis factor-α inhibitors (TNFi) on incident dementia. The objective of the analysis was to investigate the association between TNFi and the risk of incident dementia in a population undergoing treatment for rheumatological disorders. Methods: We followed patients aged ≥ 65 years with dementia and rheumatological conditions in two cohort studies, DANBIO (N = 21,538), a Danish clinical database, and AOK PLUS (N = 7112), a German health insurance database. We defined incident dementia using diagnostic codes and/or medication use and used Cox regression to compare the associations of TNFi with other rheumatological therapies on the risk of dementia. To ensure that the patients were receiving long-term medication, we included patients with rheumatic diseases and systemic therapies. Results: We observed similar trends towards a lower risk of dementia associated with TNFi versus other anti-inflammatory agents in both cohorts (hazard ratios were 0.92 [95% confidence interval 0.76, 1.10] in DANBIO and 0.89 [95% confidence interval 0.63, 1.24] in AOK PLUS, respectively). Conclusions: Tumor necrosis factor-α inhibitors may decrease the risk of incident dementia although the association did not reach statistical significance in this analysis. Further research, ideally with randomization, is needed to gauge the potential of repurposing TNFi for dementia prevention and/or treatment.
- Subjects
RHEUMATISM treatment; DEMENTIA risk factors; DIAGNOSIS of dementia; DEMENTIA prevention; ANTI-inflammatory agents; RISK assessment; RESEARCH funding; HEALTH insurance; DESCRIPTIVE statistics; CONFIDENCE intervals; DEMENTIA patients; DRUG utilization
- Publication
Drugs & Aging, 2024, Vol 41, Issue 5, p423
- ISSN
1170-229X
- Publication type
Article
- DOI
10.1007/s40266-024-01112-1