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- Title
IN VITRO ANTIDIABETIC ACTIVITY OF ROOTS OF ACHYRANTHUS ASPERA.
- Authors
Reedy, Kanala Somasekhar; Sumanth, Gopavaram; Reddy, Gorantla Suryaprakash; Tarun, Ksheerasagare; Divya, Kumbarthi Thanmaya; Survana; Ali, Osman Ali Osman
- Abstract
The present study is aimed to evaluate in vitro antidiabetic effect of Ethyl acetate and methanolic extracts of roots of Achyranthus aspera. 500 gm of the powdered roots of Achyranthus aspera were extracted by maceration method using ethyl acetate and methanol. The maceration was continued for seven days after which, the contents were filtered and concentrated by rota evaporator. Both the extracts are evaluated for in vitro antidiabetic activity (α-amylase inhibition assay, α-glucosidase inhibition assay). Ethyl acetate extract and methanolic extracts of Achyranthus aspera exhibited in vitro antidiabetic activity by inhibition of alpha amylase, alpha glucosidase with IC50 values of 25±1.83, 27.62±1.83 and 40±2.92, 38.92±1.93 respectively. The study is concluded that methanolic extract of roots of Achyranthus aspera showed better in vitro antidiabetic activity compared to ethyl acetate extract.
- Subjects
METHANOL; AMARANTHACEAE; HYPOGLYCEMIC agents
- Publication
Journal of Advanced Scientific Research, 2020, Vol 11, Issue 4, p341
- ISSN
0976-9595
- Publication type
Article