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- Title
Rod-Derived Cone Viability Factor for Treating Blinding Diseases: From Clinic to Redox Signaling.
- Authors
Léveillard, Thierry; Sahel, José-Alain
- Abstract
The identifi cation of one mechanism that causes vision loss in inherited degenerative retinal disorders revealed a new signaling molecule that represents a potential therapy for these currently untreatable diseases. This protein, called rod-derived cone viability factor (RdCVF), maintains the function and consequently the viability of cone photoreceptor cells in the retina; mice that lack this factor exhibit a progressive loss of photoreceptor cells. The gene encoding RdCVF also encodes, by diff erential splicing, a second product that has characteristics of a thioredoxin-like enzyme and protects both photoreceptor cells and, more specifi cally, its interacting protein partner, the tau protein, against oxidative damage. This signaling pathway potentially links environmental insults to an endogenous neuroprotective response.
- Publication
Science Translational Medicine, 2010, Vol 2, Issue 26, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.3000866