We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial.
- Authors
NAVARRO-LÓPEZ, Vicente; MARTÍNEZ-ANDRÉS, Asunción; RAMÍREZ-BOSCÀ, Ana; RUZAFA-COSTAS, Beatriz; NÚÑEZ-DELEGIDO, Eva; CARRIÓN-GUTIÉRREZ, Miguel A.; PRIETO-MERINO, David; CODOÑER-CORTÉS, Francisco; RAMÓN-VIDAL, Daniel; GENOVÉS-MARTÍNEZ, Salvador; CHENOLL-CUADROS, Empar; PÉREZ-ORQUÍN, José M.; PICÓ-MONLLOR, Jose A.; CHUMILLAS-LIDÓN, Sara
- Abstract
The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.
- Subjects
CLINICAL trials; PSORIASIS; GUT microbiome
- Publication
Acta Dermato-Venereologica, 2019, Vol 99, Issue 12, p1078
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-3305