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- Title
Association of serum gamma-glutamyltransferase and premature coronary artery disease.
- Authors
Sheikh, M.; Tajdini, M.; Shafiee, A.; Sotoudeh Anvari, M.; Jalali, A.; Poorhosseini, H.; Amirzadegan, A.
- Abstract
Background: Serum gamma-glutamyltransferase (GGT) has been introduced as a predictive factor for cardiovascular disease. In this study, we investigated the association of serum GGT and premature coronary artery disease (CAD) in candidates for coronary angiography. Methods: In this cross-sectional study, we enrolled male subjects aged ≤45 years and female subjects ≤55 years who were candidates for elective coronary angiography due to typical chest pain or a positive non-invasive test. Baseline characteristics were recorded for all the participants and serum levels of blood glucose, lipid profile and GGT were measured. Patients were divided into CAD and non-CAD groups based on angiography for further comparisons. Results: From a total of 367 patients (age 45.1 ± 6.1 years, 161 males [43.9%]), 176 (47.9%) patients had premature CAD. A high level of GGT was significantly associated with the presence of CAD ( p < 0.001). A 10-unit increase in GGT could strongly predict the presence of premature coronary artery disease (OR: 13.34, 95% CI: 7.19-24.78; p < 0.001) after adjustment for confounders. The area under the receiver operating characteristic curve for GGT was 80.9% (range 76.5-85.3) and the sensitivity and specificity of GGT at a cut-point of 22.5 IU/l was 80.1% and 70.2%, respectively. Diagnostic accuracy of GGT was 74.9%. The positive predictive value and negative predictive value for GGT was 71.3 and 79.3, respectively. Conclusion: We observed that GGT levels in patients with typical chest pain or positive non-invasive tests could predict the presence of premature CAD in young patients.
- Subjects
GAMMA-glutamyltransferase; CARDIOVASCULAR diseases risk factors; CORONARY angiography; CHEST pain; CARDIOVASCULAR diseases; PATIENTS; CROSS-sectional method
- Publication
Netherlands Heart Journal, 2017, Vol 25, Issue 7/8, p439
- ISSN
1568-5888
- Publication type
Article
- DOI
10.1007/s12471-017-0964-5