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- Title
OXIDATIVE STRESS IN EXPERIMENTAL HYPOTHYROIDISM: EFFECT OF VITAMIN E SUPPLEMENTATION.
- Authors
Petrulea, Mirela Sanda; Duncea, Ileana; Hazi, Georgeta; Dragotoiu, Gheorghe; Decea, Nicoleta; Mureşan, Adriana
- Abstract
Oxidative stress may result from either overproduction of free radicals or from insufficiency of several antioxidant defence systems. Thyroid hormones have well-known effects on mitochondrial oxygen consumption, but data about how hypothyroidism affects oxidative stress are controversial. The aim of the study was to investigate the oxidant and antioxidant status in propylthiouracil-induced hypothyroidism and the effect of vitamin E supplementation on this experimental model. Materials and Methods. Thirty male Wistar rats were used in the study. Hypothyroidism was induced by administering Propylthiouracil (5mg/100g animal /day) for 30 days. Plasma was used to determine malondialdehyde (MDA), carbonyl proteins, SH groups, glutathion (GSH) and superoxide dismutase (SOD) while MDA, carbonyl proteins, SH groups and GSH were determined from the thyroid gland. Results. In plasma and thyroid homogenate of hypothyroid rats, the lipid peroxidation did not differ significantly from the control group. Carbonyl proteins levels increased significantly in serum and thyroid tissue of hypothyroid animals as compared to the control group. Antioxidant parameters SH groups, GSH and SOD levels did not show any significant changes. Vitamin E supplementation significantly increased carbonyl proteins levels and decreased SH, GSH and SOD levels compared with the Propylthiouracil treated group. Conclusions. Our study suggests an elevated reactive oxygen species which may be a result of increased oxidative stress.
- Subjects
OXIDATIVE stress -- Risk factors; ANTIOXIDANTS &; health; VITAMIN E; HYPOTHYROIDISM; THYROID hormones; BLOOD plasma; MALONDIALDEHYDE; GLUTATHIONE; SUPEROXIDE dismutase
- Publication
Clujul Medical, 2010, Vol 83, Issue 2, p245
- ISSN
1222-2119
- Publication type
Article