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- Title
Effect of herbal drug supplementation in pharmacokinetics and pharmacodynamics of sulfonylureas.
- Authors
Awasthi, Kamlesh; Jyothi, Y.; Rajendra, S. V.; Bhatt, Dipendra; Gowthami, V.; Banakar, Vidya
- Abstract
Sulfonylureas are the agents that cause or stimulate secretion of insulin, which are beneficial in the Type 2 diabetes mellitus treatment. There will be a high chance of drug interaction to the patient those who consume sulfonylureas along with other herbal medicines. The aim of this analysis is to present the herbal drugs with potential interactions of antidiabetic sulfonylureas. Sulfonylureas are mainly metabolized by the enzymes CYP2C9 and CYP3A4 and the herbs such as St. John's wort and Ginkgo biloba produce CYP2C9 influenced metabolism of sulfonylureas. Whereas, fruits, including pineapple juice, pomegranate, and cassia, hinder its metabolism. Herbs with antidiabetic nature such as Aloe vera, sesame, neem, ginseng, and Andrographis paniculata pharmacodynamically increase the hypoglycemic activity of sulfonylureas. Several herbal supplements can interact pharmacokinetically and some herbal medicines are pharmacodynamically associated with sulfonylureas.
- Subjects
PHARMACOKINETICS; GINKGO; ANDROGRAPHIS paniculata; PHARMACOLOGY; HYPOGLYCEMIC sulfonylureas; TYPE 2 diabetes; PHARMACODYNAMICS
- Publication
Drug Invention Today, 2020, Vol 14, Issue 2, p284
- ISSN
0975-7619
- Publication type
Article