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- Title
Anti-inflammatory activity of Murraya koenigii – An in vitro study.
- Authors
Sriram, Kadambari; Vishnpriya, V.; Ponnulakshmi, R.; Gayathri, R.; Madhan, K.; Shyamaladevi, B.; Selvaraj, J.
- Abstract
Background: In the ancient time, many naturally occurring plants played an important role in discovery in many therapeutic agents. It has been shown to have beneficial role such as therapeutic uses include beneficial effects on the cardiovascular system, antibiotic, anticancer, anti-inflammatory, and hypoglycemic effects. Objective: The study was designed to evaluate the anti-inflammatory effect of Murraya koenigii leaf ethanolic extract by in vitro analysis. Materials and Methods: The plant leaf powder was loaded into Soxhlet extractor and subjected to extraction with ethanol. After extraction, the solvent was distilled off and the extracts were concentrated on water bath to a dry residue and kept in a desiccator. Results: Protein denaturation is a process, in which proteins lose their tertiary structure and secondary structure by the application of external stress or compound, such as strong acid or base, a concentrated inorganic salt, an organic solvent, or heat. Denaturation of proteins is a well-documented cause of inflammation. As part of the investigation on the mechanism of the anti-inflammation activity, ability of plant extract to inhibit protein denaturation was studied. It was effective in inhibiting heat-induced albumin denaturation. Maximum inhibition of 88% was observed at 500 μg/ml. Aspirin, a standard anti-inflammatory drug showed the maximum inhibition of 99% at the concentration of 100 μg/ml compared with control. Conclusions: Results indicate that the ethanol extracts of M. koenigii possess anti-inflammatory properties. These activities may be due to the strong occurrence of polyphenolic compounds such as alkaloids, flavonoids, tannins, steroids, and phenols. The extract fractions serve as free radical inhibitors or scavenger or acting possibly as primary oxidants and inhibited the heat-induced albumin denaturation.
- Subjects
CURRY leaf tree; DENATURATION of proteins; TANNINS; ASPIRIN; FREE radical scavengers; ORGANIC solvents; IN vitro studies
- Publication
Drug Invention Today, 2019, Vol 11, Issue 10, p2384
- ISSN
0975-7619
- Publication type
Article