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- Title
Remedial effects of β-sitosterol in high-fat diet-induced oxidative stress in experimental rats.
- Authors
Akilarooran, A.; Vishnupriya, V.; Ponnulakshmi, R.; Gayathri, R.; Madhan, K.; Shyamaladevi, B.; Selvaraj, J.
- Abstract
Background: β-sitosterol is a naturally occurring plant sterol, ubiquitously found in many plants. It has been shown to reduce hyperglycemia and hyperinsulinemia in experimental mice model. Despite the effect of β-sitosterol on oxidative stress in high-fat diet (HFD) fed type-2 diabetic rats is not known. Objectives: The study aimed to identify the remedial effects of β-sitosterol in HFD-induced oxidative stress in experimental rats. Methodology: Adult male albino rats of Wistar strain 150-180 days old with 180-200 g body weight were randomly divided into four groups of six rats each: Group I - normal rats; Group II - type 2 diabetic rats; Group III - type 2 diabetic rat treated with β-sitosterol (20 mg/kg b.wt/day), orally for 30 days; Group IV - type 2 diabetic rats treated with metformin (50 mg/kg, b.wt/day orally for 30 days). After the treatment period, animals were anesthetized and the liver from control and experimental animals was immediately dissected and used for the further study. Results: In type 2 diabetic animals, compared to control, the hydrogen peroxide (H2O2), hydroxyl radical (OH*), and lipid peroxidation (LPO) in the liver of diabetic rats were significantly raised. β-sitosterol notably brought down the rise in H2O2, OH*, and LPO. Conclusion: Our present finding indicates that the antidiabetic activity of β-sitosterol on oxidative stress in HFD fed type-2 diabetic rats.
- Subjects
STREPTOZOTOCIN; OXIDATIVE stress; RATS; HIGH-fat diet; HYDROXYL group; HYDROGEN peroxide
- Publication
Drug Invention Today, 2019, Vol 12, Issue 5, p910
- ISSN
0975-7619
- Publication type
Article