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- Title
An efficient and stereoselective synthesis of Levetiracetam: An anticonvulsant drug.
- Authors
Raju, Veeramalla; Somaiah, Sripathi; Sashikanth, Suthrapu; Laxminarayana, Eppakayala; Mukkanti, Kagga
- Abstract
Aim: To synthesise (S)-α-ethyl-2-oxo-1-pyrrolidine acetamide, Levetiracetam by using (R)-1-(1-hydroxymethylpropyl) pyrrolidin-2-one as a chiral auxiliary. Methods: The 1H and 13C spectra were recorded in CDCl3 at 400 MHz on varian Gemini 400 MHz FT NMR spectrometer. The chemical shifts were reported in d ppm relative to TMS. The FT-IR spectra were recorded in the solid state as KBr dispersion using a Perkin-Elmer 1650 FT-IR spectrometer. The mass spectrum (70eV) was recorded on an Agilent-6310 LC-MS spectrometer. Organic solvents were distilled before use or, if otherwise noted, dried according to the typical procedures. Conclusion: A highly stereoselective synthesis for the preparation of levetiracetam has been achieved by the asymmetric alkylation reaction.
- Subjects
STEREOSELECTIVE reactions; ANTICONVULSANTS; DRUG synthesis; ACETAMIDE; CHIRAL drugs; FOURIER transform infrared spectroscopy; ALKYLATION
- Publication
Drug Invention Today, 2014, Vol 6, Issue 1, p32
- ISSN
0975-7619
- Publication type
Article