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- Title
Comparative Study of Thick Smear, Thin Smear, QBC and Antigen Card Test in Diagnosis of Malaria.
- Authors
J. Jafar Ebrahim; I. Al-Ghonaim Mohammed; Maghram Al-Amri; H. Abdel-Ghaffar Mamdouh; N. Ramprasad; R. Farhan Khan
- Abstract
Rapid diagnosis is pre-requisite for institution of effective treatment and reducing mortality and morbidity of malaria. The study was taken up to compare the efficiency of various methods available, i.e. thick and thin smear, Quantitative Buffy Coat (QBC) and Antigen card test (Parascreen). In the present study, thick smear was compared with thin smear, QBC and Antigen card test for the diagnosis of malaria. A total of 406 samples were collected from patients presenting with classic symptoms of malaria. For traditional microscopy; thick and thin smear were prepared and stained with Leishman's stain, taking thick smear as a gold standard. QBC and Antigen detection were done using commercially available kits. Malaria was diagnosed in 112, 81, 98 and 110 patient by thick smear, thin smear, QBC and antigen card test respectively. In antigen card test the sensitivity 98.2%, specificity 100%, Positive predictive value (PPV) 100% and Negative predictive value (NPV) 99.3% were observed. Although the antigen card test is superior than thin smear and QBC. Antigen card test has its advantages in terms of speed, sensitivity and specificity especially in an endemic area. Therefore we recommended antigen card test which was simple, reliable and effective for the diagnosis of malaria in remote and rural areas of our country.
- Subjects
MALARIA diagnosis; ANTIGENS; BUFFY coat; MICROSCOPY; MORTALITY
- Publication
International Journal of Pure & Applied Sciences & Technology, 2013, Vol 17, Issue 1, p54
- ISSN
2229-6107
- Publication type
Article