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- Title
Impact of salbutamol on muscle metabolism assessed by <sup>31</sup> P NMR spectroscopy.
- Authors
Decorte, N.; Lamalle, L.; Carlier, P.G.; Giacomini, E.; Guinot, M.; Levy, P.; Verges, S.; Wuyam, B.
- Abstract
The potential ergogenic effects of oral salbutamol intake were demonstrated for decades but the underlying mechanisms remain to elucidate. We hypothesized that improved exercise performance after acute oral salbutamol administration is associated with changes in muscle metabolism. Twelve healthy, nonasthmatic, moderately trained, male subjects were recruited to compare in a double-blind crossover randomized study, an oral dose of salbutamol (4 mg) and a placebo. After treatment administration, subjects performed repetitive plantar flexions to exhaustion in a 3 T magnet. Continuous 31 P nuclear magnetic resonance spectroscopy assessment of the calf muscles was performed at rest, during exercise, and during recovery. No significant difference between treatments was detected in metabolite concentration at rest ( P > 0.05). Creatine phosphate and inorganic phosphate changes during and immediately after exercise were similar between treatments ( P > 0.05). Intramuscular pH ( pHi) was significantly higher at rest, at submaximal exercise but not at exhaustion with salbutamol ( pHi at 50% of exercise duration, 6.8 ± 0.1/6.9 ± 0.1 for placebo and salbutamol, respectively, P < 0.05). The maximal power (28 ± 7 W/23 ± 7 W; P = 0.001) and total work (1702 ± 442 J/1381 ± 432 J; P = 0.003) performed during plantar flexions were significantly increased with salbutamol. Salbutamol induced significant improvement in calf muscle endurance with similar metabolic responses during exercise, except slight differences in pHi. Other mechanisms than changes in muscle metabolism may be responsible for the ergogenic effect of salbutamol administration.
- Subjects
ALBUTEROL; ANALYSIS of variance; ANKLE; CARDIOPULMONARY system; CROSSOVER trials; DYNAMICS; EXERCISE tests; HYDROGEN-ion concentration; RANGE of motion of joints; NUCLEAR magnetic resonance spectroscopy; PLACEBOS; PROBABILITY theory; ERGOGENIC aids; BODY movement; RANDOMIZED controlled trials; REPEATED measures design; BLIND experiment; DATA analysis software; SKELETAL muscle; DESCRIPTIVE statistics
- Publication
Scandinavian Journal of Medicine & Science in Sports, 2015, Vol 25, Issue 3, pe267
- ISSN
0905-7188
- Publication type
Article
- DOI
10.1111/sms.12312