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- Title
Additive value of 3T cardiovascular magnetic resonance coronary angiography for detecting coronary artery disease.
- Authors
Zhang, Lijun; Song, Xiantao; Dong, Li; Li, Jianan; Dou, Ruiyu; Fan, Zhanming; An, Jing; Li, Debiao
- Abstract
Background: The purpose of the work was to evaluate the incremental diagnostic value of free-breathing, contrast-enhanced, whole-heart, 3 T cardiovascular magnetic resonance coronary angiography (CE-MRCA) to stress/rest myocardial perfusion imaging (MPI) and late gadolinium enhancement (LGE) imaging for detecting coronary artery disease (CAD). Methods: Fifty-one patients with suspected CAD underwent a comprehensive cardiovascular magnetic resonance (CMR) examination (CE-MRCA, MPI, and LGE). The additive diagnostic value of MRCA to MPI and LGE was evaluated using invasive x-ray coronary angiography (XA) as the standard for defining functionally significant CAD (≥ 50% stenosis in vessels > 2 mm in diameter). Results: 90.2% (46/51) patients (54.0 ± 11.5 years; 71.7% men) completed CE-MRCA successfully. On per-patient basis, compared to MPI/LGE alone or MPI alone, the addition of MRCA resulted in higher sensitivity (100% vs. 76.5%, <italic>p</italic> < 0.01), no change in specificity (58.3% vs. 66.7%, <italic>p</italic> = 0.6), and higher accuracy (89.1% vs 73.9%, <italic>p</italic> < 0.01) for CAD detection (prevalence = 73.9%). Compared to LGE alone, the addition of CE-MRCA resulted in higher sensitivity (97.1% vs. 41.2%, <italic>p</italic> < 0.01), inferior specificity (83.3% vs. 91.7%, <italic>p</italic> = 0.02), and higher diagnostic accuracy (93.5% vs. 54.3%, <italic>p</italic> < 0.01). Conclusion: The inclusion of successful free-breathing, whole-heart, 3 T CE-MRCA significantly improved the sensitivity and diagnostic accuracy as compared to MPI and LGE alone for CAD detection.
- Subjects
CORONARY disease; DIAGNOSIS; DIAGNOSTIC imaging; PERFUSION; RADIONUCLIDE imaging; RESEARCH evaluation; DISEASE prevalence; CONTRAST media; CORONARY angiography; MAGNETIC resonance angiography
- Publication
Journal of Cardiovascular Magnetic Resonance (BioMed Central), 2018, Vol 20, Issue 1, pN.PAG
- ISSN
1532-429X
- Publication type
Article
- DOI
10.1186/s12968-018-0450-2