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- Title
DNA synthesis in peripheral blood leucocytes following renal transplantation.
- Authors
Jones, Alfred L.; Uldall, Peter R.
- Abstract
DNA synthesis in peripheral blood leucocytes following renal transplantation was measured during the post-operative period in 22 renal allografted patients. Significant increases in synthesis were considered in relation to rejection episodes and immunosuppressive therapy. Results in 17 patients with good renal function showed a correlation between acute rejection episodes and the presence of a preceding or coincident period of increased DNA synthesis. Absence of rejection was associated with an absence of any increase in synthesis. Corticosteroid-induced granulocytosis characterized by immature DNA-synthesizing myeloid cells did not appear to be reflected in the levels of DNA synthesis unless prednisone in excess of 100 mg/day was administered. In oliguric patients treated with high doses of prednisone (> 200 mg/day), high levels of DNA synthesis occurred following drug administration. It is concluded that in order for measurement of DNA synthesis to be of use in the detection of rejection, particularly in oliguric patients. it is necessary to assess DNA synthesis in lymphocyte suspensions free of any myeloid cells.
- Subjects
DNA synthesis; DNA; DEOXYRIBOSE; LEUCOCYTES; BLOOD cells; KIDNEY transplantation
- Publication
Kidney International, 1974, Vol 5, Issue 5, p378
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1974.54