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Absorption, distribution, metabolism, and excretion of [14C]-dasotraline in humans.
Published in:
Pharmacology Research & Perspectives, 2017, v. 5, n. 1, p. n/a, doi. 10.1002/prp2.281
By:
- Chen, Yu‐Luan;
- Skende, Estela;
- Lin, Jing;
- Yi, Yijun;
- Wang, Peter L.;
- Wills, Sarah;
- Wilkinson, H. Scott;
- Koblan, Kenneth S.;
- Hopkins, Seth C.
Publication type:
Article
Transformed PANSS Factors Intended to Reduce Pseudospecificity Among Symptom Domains and Enhance Understanding of Symptom Change in Antipsychotic-Treated Patients With Schizophrenia.
Published in:
Schizophrenia Bulletin, 2018, v. 44, n. 3, p. 593, doi. 10.1093/schbul/sbx101
By:
- Hopkins, Seth C.;
- Ogirala, Ajay;
- Loebel, Antony;
- Koblan, Kenneth S.
Publication type:
Article
Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice.
Published in:
2009
By:
- Uebele, Victor N.;
- Gotter, Anthony L.;
- Nuss, Cindy E.;
- Kraus, Richard L.;
- Doran, Scott M.;
- Garson, Susan L.;
- Reiss, Duane R.;
- Yuxing Li;
- Barrow, James C.;
- Reger, Thomas S.;
- Zhi-Qiang Yang;
- Ballard, Jeanine E.;
- Cuyue Tang;
- Metzger, Joseph M.;
- Sheng-Ping Wang,4 Kenneth S. Koblan,4 and John J. Renger1;
- Li, Yuxing;
- Yang, Zhi-Qiang;
- Tang, Cuyue;
- Wang, Sheng-Ping;
- Koblan, Kenneth S
Publication type:
journal article
Effect of TAAR1/5-HT1A agonist SEP-363856 on REM sleep in humans.
Published in:
Translational Psychiatry, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41398-021-01331-9
By:
- Hopkins, Seth C.;
- Dedic, Nina;
- Koblan, Kenneth S.
Publication type:
Article
In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT1A Receptor Agonist for the Treatment of Schizophrenia.
Published in:
Pharmaceutical Research, 2022, v. 39, n. 5, p. 837, doi. 10.1007/s11095-022-03267-1
By:
- Xiao, Guangqing;
- Chen, Yu-Luan;
- Dedic, Nina;
- Xie, Linghong;
- Koblan, Kenneth S.;
- Galluppi, Gerald R.
Publication type:
Article
TAAR1 agonist ulotaront delays gastric emptying of solids in patients with schizophrenia and concurrent metabolic syndrome with prediabetes.
Published in:
Diabetes, Obesity & Metabolism, 2024, v. 26, n. 6, p. 2466, doi. 10.1111/dom.15569
By:
- Milanović, Snežana;
- Dedic, Nina;
- Lew, Robert;
- Burton, Duane;
- Koblan, Kenneth S.;
- Camilleri, Michael;
- Hopkins, Seth C.
Publication type:
Article
Uncovering the Genetic Landscape for Multiple Sleep- Wake Traits.
Published in:
PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005161
By:
- ,4Winrow, Christopher J.;
- Williams, Deanna L.;
- Kasarskis, Andrew;
- Millstein, Joshua;
- Laposky, Aaron D.;
- Yang, He S.;
- Mrazek, Karrie;
- Zhou, Lili;
- Owens, Joseph R.;
- Radzicki, Daniel;
- Preuss, Fabian;
- Schadt, Eric E.;
- Shimomura, Kazuhiro;
- Vitaterna, Martha H.;
- Chunsheng Zhang;
- Koblan, Kenneth S.;
- Renger, John J.;
- Turek, Fred W.
Publication type:
Article
Generation and Characterization of a Cell Line with Inducible Expression of Cav3.2 (T-Type) Channels.
Published in:
Assay & Drug Development Technologies, 2003, v. 1, n. 5, p. 637
By:
- Menghang Xia;
- John P. Imredy;
- Vincent P. Santarelli;
- Hongyu Annie Liang;
- Cindra L. Condra;
- Paul Bennett;
- Kenneth S. Koblan;
- Thomas M. Connolly
Publication type:
Article
High Throughput Ion-Channel Pharmacology: Planar-Array-Based Voltage Clamp.
Published in:
Assay & Drug Development Technologies, 2003, v. 1, p. 127, doi. 10.1089/154065803321537845
By:
- Kiss, Laszlo;
- Bennett, Paul B.;
- Uebele, Victor N.;
- Koblan, Kenneth S.;
- Kane, Stefanie A.;
- Neagle, Brad;
- Schroeder, Kirk
Publication type:
Article
Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy.
Published in:
Schizophrenia (2754-6993), 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41537-023-00385-6
By:
- Perini, Francesca;
- Nazimek, Jadwiga Maria;
- Mckie, Shane;
- Capitão, Liliana P.;
- Scaife, Jessica;
- Pal, Deepa;
- Browning, Michael;
- Dawson, Gerard R.;
- Nishikawa, Hiroyuki;
- Campbell, Una;
- Hopkins, Seth C.;
- Loebel, Antony;
- Elliott, Rebecca;
- Harmer, Catherine J.;
- Deakin, Bill;
- Koblan, Kenneth S.
Publication type:
Article
Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry.
Published in:
BMC Neuroscience, 2002, v. 3, p. 11, doi. 10.1186/1471-2202-3-11
By:
- Hong Sun;
- Jian Xu;
- Della Penna, Kimberly B.;
- Benz, Robert J.;
- Kinose, Fumi;
- Holder, Daniel J.;
- Koblan, Kenneth S.;
- Gerhold, David L.;
- Hao Wang
Publication type:
Article
Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults.
Published in:
Neuropsychopharmacology, 2015, v. 40, n. 12, p. 2745, doi. 10.1038/npp.2015.124
By:
- Koblan, Kenneth S;
- Hopkins, Seth C;
- Sarma, Kaushik;
- Jin, Fengbin;
- Goldman, Robert;
- Kollins, Scott H;
- Loebel, Antony
Publication type:
Article
Efficacy and Safety of Dasotraline in Children With ADHD: A Laboratory Classroom Study.
Published in:
Journal of Attention Disorders, 2020, v. 24, n. 2, p. 192, doi. 10.1177/1087054719864644
By:
- Wigal, Sharon B.;
- Hopkins, Seth C.;
- Koblan, Kenneth S.;
- Childress, Ann;
- Kent, Justine M.;
- Tsai, Joyce;
- Hsu, Jay;
- Loebel, Antony;
- Goldman, Robert
Publication type:
Article
Efficacy and Safety of Dasotraline in Children With ADHD: A Laboratory Classroom Study.
Published in:
2020
By:
- Wigal, Sharon B;
- Hopkins, Seth C;
- Koblan, Kenneth S;
- Childress, Ann;
- Kent, Justine M;
- Tsai, Joyce;
- Hsu, Jay;
- Loebel, Antony;
- Goldman, Robert
Publication type:
journal article
Understanding Antipsychotic Drug Treatment Efects: A Novel Method to Reduce Pseudospeciicity of the Positive and Negative Syndrome Scale (PANSS) Factors.
Published in:
Innovations in Clinical Neuroscience, 2017, v. 14, n. 11/12, p. 54
By:
- HOPKINS, SETH C.;
- OGIRALA, AJAY;
- LOEBEL, ANTONY;
- KOBLAN, KENNETH S.
Publication type:
Article
Dasotraline Is Clinically Effective for Adults With ADHD.
Published in:
MD Conference Express, 2015, v. 15, n. 11, p. 3, doi. 10.1177/1559897715593746
By:
- Hoyle, Brian;
- Koblan, Kenneth S.
Publication type:
Article
Discovery and Model‐Informed Drug Development of a Controlled‐Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 2, p. 460, doi. 10.1002/cpt.3311
By:
- Hopkins, Seth C.;
- Toongsuwan, Siriporn;
- Corriveau, Taryn J.;
- Watanabe, Takao;
- Tsushima, Yuki;
- Asada, Takumi;
- Lew, Robert;
- Shi, Lei;
- Zann, Vanessa;
- Snowden, Thomas J.;
- van der Graaf, Piet H.;
- Darpo, Borje;
- Searle, Graham E.;
- Rabiner, Eugenii A.;
- Wilding, Ian;
- Szabo, Steven T.;
- Galluppi, Gerald R.;
- Koblan, Kenneth S.
Publication type:
Article
Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5‐HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders.
Published in:
Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 3, p. 808, doi. 10.1002/cpt.2282
By:
- Hopkins, Seth C.;
- Wilkinson, Scott;
- Corriveau, Taryn J.;
- Nishikawa, Hiroyuki;
- Nakamichi, Keiko;
- Loebel, Antony;
- Koblan, Kenneth S.
Publication type:
Article
Population pharmacokinetic analysis of ulotaront in subjects with schizophrenia.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1245, doi. 10.1002/psp4.12692
By:
- Galluppi, Gerald R.;
- Polhamus, Daniel G.;
- Fisher, Jeannine M.;
- Hopkins, Seth C.;
- Koblan, Kenneth S.
Publication type:
Article
Depicting Risperidone Safety Profiles in Clinical Trials Across Different Diagnoses Using a Dopamine D2-Based Pharmacological Class Effect Query Defined by FAERS.
Published in:
Clinical Drug Investigation, 2022, v. 42, n. 12, p. 1113, doi. 10.1007/s40261-022-01218-7
By:
- Hopkins, Seth C.;
- Ogirala, Ajay;
- Zeni, Courtney;
- Worden, MaryAlice;
- Koblan, Kenneth S.
Publication type:
Article
Depicting Safety Profile of TAAR1 Agonist Ulotaront Relative to Reactions Anticipated for a Dopamine D2-Based Pharmacological Class in FAERS.
Published in:
Clinical Drug Investigation, 2021, v. 41, n. 12, p. 1067, doi. 10.1007/s40261-021-01094-7
By:
- Hopkins, Seth C.;
- Ogirala, Ajay;
- Worden, MaryAlice;
- Koblan, Kenneth S.
Publication type:
Article
Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans.
Published in:
Neurology & Therapy, 2023, v. 12, n. 3, p. 815, doi. 10.1007/s40120-023-00459-8
By:
- Chen, Yu-Luan;
- Tsukada, Hironobu;
- Milanovic, Snezana;
- Shi, Lei;
- Li, Yan;
- Mao, Yongcai;
- Koblan, Kenneth S.;
- Galluppi, Gerald R.
Publication type:
Article
The rate of dasotraline brain entry is slow following intravenous administration.
Published in:
Psychopharmacology, 2020, v. 237, n. 11, p. 3435, doi. 10.1007/s00213-020-05623-8
By:
- Lew, Robert;
- Constantinescu, Cristian C.;
- Holden, Daniel;
- Carson, Richard E.;
- Carroll, Vincent;
- Galluppi, Gerald;
- Koblan, Kenneth S.;
- Hopkins, Seth C.
Publication type:
Article
Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N, N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats.
Published in:
ChemMedChem, 2009, v. 4, n. 7, p. 1069, doi. 10.1002/cmdc.200900069
By:
- Whitman, David B.;
- Cox, Christopher D.;
- Breslin, Michael J.;
- Brashear, Karen M.;
- Schreier, John D.;
- Bogusky, Michael J.;
- Bednar, Rodney A.;
- Lemaire, Wei;
- Bruno, Joseph G.;
- Hartman, George D.;
- Reiss, Duane R.;
- Harrell, C. Meacham;
- Kraus, Richard L.;
- Li, Yuxing;
- Garson, Susan L.;
- Doran, Scott M.;
- Prueksaritanont, Thomayant;
- Li, Chunze;
- Winrow, Christopher J.;
- Koblan, Kenneth S.
Publication type:
Article
A Novel Method for Deriving Adverse Event Prevalence in Randomized Controlled Trials: Potential for Improved Understanding of Benefit-Risk Ratio and Application to Drug Labels.
Published in:
Advances in Therapy, 2024, v. 41, n. 1, p. 152, doi. 10.1007/s12325-023-02695-8
By:
- Piacentino, Daria;
- Ogirala, Ajay;
- Lew, Robert;
- Loftus, Gregory;
- Worden, MaryAlice;
- Koblan, Kenneth S.;
- Hopkins, Seth C.
Publication type:
Article

Found: 25

Absorption, distribution, metabolism, and excretion of [<sup>14</sup>C]-dasotraline in humans.

Transformed PANSS Factors Intended to Reduce Pseudospecificity Among Symptom Domains and Enhance Understanding of Symptom Change in Antipsychotic-Treated Patients With Schizophrenia.

Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice.

Effect of TAAR1/5-HT1A agonist SEP-363856 on REM sleep in humans.

In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT<sub>1A</sub> Receptor Agonist for the Treatment of Schizophrenia.

TAAR1 agonist ulotaront delays gastric emptying of solids in patients with schizophrenia and concurrent metabolic syndrome with prediabetes.

Uncovering the Genetic Landscape for Multiple Sleep- Wake Traits.

Generation and Characterization of a Cell Line with Inducible Expression of Cav3.2 (T-Type) Channels.

High Throughput Ion-Channel Pharmacology: Planar-Array-Based Voltage Clamp.

Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy.

Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry.

Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults.

Efficacy and Safety of Dasotraline in Children With ADHD: A Laboratory Classroom Study.

Efficacy and Safety of Dasotraline in Children With ADHD: A Laboratory Classroom Study.

Understanding Antipsychotic Drug Treatment Efects: A Novel Method to Reduce Pseudospeciicity of the Positive and Negative Syndrome Scale (PANSS) Factors.

Dasotraline Is Clinically Effective for Adults With ADHD.

Discovery and Model‐Informed Drug Development of a Controlled‐Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.

Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5‐HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders.

Population pharmacokinetic analysis of ulotaront in subjects with schizophrenia.

Depicting Risperidone Safety Profiles in Clinical Trials Across Different Diagnoses Using a Dopamine D<sub>2</sub>-Based Pharmacological Class Effect Query Defined by FAERS.

Depicting Safety Profile of TAAR1 Agonist Ulotaront Relative to Reactions Anticipated for a Dopamine D2-Based Pharmacological Class in FAERS.

Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans.

The rate of dasotraline brain entry is slow following intravenous administration.

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N, N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats.

A Novel Method for Deriving Adverse Event Prevalence in Randomized Controlled Trials: Potential for Improved Understanding of Benefit-Risk Ratio and Application to Drug Labels.