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- Title
Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells.
- Authors
Shahwar, Durre; Ullaha, Sami; Khan, Mohammad Akmal; Ahmad, Naeem; Saeed, Afifa; Ullah, Saif
- Abstract
Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, ¹H and 13C NMR). Compound 1 exhibited highest cytotoxicity with 90.16±1.06% inhibition (IC50=5.30 x 10-4 mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10-3 mg/ml), while compounds 3 and 4 were inactive in the bioassay.
- Subjects
OVARIAN cancer treatment; ANTINEOPLASTIC agents; CINNAMON; LEAVES; BIOLOGICAL assay; CANCER cells
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2015, Vol 28, Issue 3, p969
- ISSN
1011-601X
- Publication type
Article