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- Title
Synthesis, characterization, biological evaluation and QSAR of some Schiff base esters: Promising new antitumor, antioxidant and anti-inflammatory agents.
- Authors
Noureen, Asma; Saleem, Samreen; Fatima, Tabinda; Siddiqi, Humaira Masood; Mirza, Bushra
- Abstract
We report the synthesis, characterization, biological evaluation and quantitative structure-activity relationship of some Schiff base esters as promising new antitumor, antioxidant and anti-inflammatory agents. The Schiff base esters were synthesized by two synthetic routes using variably substituted hydroxy benzaldehydes with para amino phenol in appreciable yields. All the newly synthesized esters have been characterized by ¹H-NMR, 13C-NMR, FT-IR techniques and elemental analysis. The synthesized esters were examined for antioxidant, antitumor and anti-inflammatory potentials through different bioassays and quantitative structure-activity relationship was studied. Bioassays showed encouraging results and indicated that some of these title compounds may have potential for further pharmacological investigations.
- Subjects
QSAR models; SCHIFF bases; ESTERS; CHEMICAL synthesis; ANTINEOPLASTIC agents; ANTIOXIDANTS; ANTI-inflammatory agents; FREE radicals; DNA damage
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2013, Vol 26, Issue 1, p113
- ISSN
1011-601X
- Publication type
Article